St. John's wort may help to address the following conditions:
human immunodeficiency virus
Although St. John's wort was shown in some initial studies to be active against the HIV virus, clinical studies have not supported the herb's efficacy in combating disease progression. St. John's wort has been shown to reduce the effectiveness of some antiviral drugs, so it should not be used for depression by patients who are taking antivirals.
A standardized extract of St. John's wort, in one study, was found to reduce psychological and psychosomatic symptoms -- issues like mood and feeling of well being -- in pre- and postmenopausal women. A treatment combining black cohosh and St. John's wort was found in another study to reduce sweating and hot flashes by 50 percent and depression by 41 percent, versus 19 and 12 percent, respectively, for placebo.
cold sores
St. John's wort inhibits replication of several viruses, including the herpes cold sore virus, and may help to prevent outbreaks when taken orally. Applied topically to an existing sore, the oil can speed recovery.
St. John's wort helps relieve mild to moderate depression -- relieving symptoms in 67% of those afflicted, in one study.
Hypericin, the main constituent of St. John's wort, has been used experimentally to locate cancer sites for laser treatment. Bladder tumors showed up red in blue light, due to hypericin's tendency to collect in tumor cells. Tumors could then be eradicated using laser treatment.
colitis/inflammatory bowel disorders
St. John's wort has antiviral activity effective against the "envelope" of the cytomegalovirus that is associated with ulcerative colitis.
St. John's wort wards off flu, Epstein-Barr, and herpes viruses.
viral infection
St. John's wort wards off flu, Epstein-Barr, and herpes viruses.
carpal tunnel syndrome
St. John's wort, when applied to the wrists as a topical cream, can reduce inflammation of connective tissues and muscles and reduce pain in cases of carpal tunnel syndrome.

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